2018 Vol. 9, No. 2

Mammalian carboxylesterases (EC 3.1.1.1) have been
demonstrated to hydrolyze endogenous esters and thioesters
including lipids. Recent studies have revealed the role of
carboxylesterases in lipid metabolism and their relevance
to metabolic diseases. To translate pre-clinical studies in
cellular and mouse models to humans, differences and
similarities of carboxylesterases between mice and human
need to be elucidated. Jihong Lian and colleagues review
current knowledge and research progression in the structure
and function of mouse and human carboxylesterases, with
emphasis on physiological roles of these enzymes in lipid
metabolism and human diseases.
demonstrated to hydrolyze endogenous esters and thioesters
including lipids. Recent studies have revealed the role of
carboxylesterases in lipid metabolism and their relevance
to metabolic diseases. To translate pre-clinical studies in
cellular and mouse models to humans, differences and
similarities of carboxylesterases between mice and human
need to be elucidated. Jihong Lian and colleagues review
current knowledge and research progression in the structure
and function of mouse and human carboxylesterases, with
emphasis on physiological roles of these enzymes in lipid
metabolism and human diseases.