2019 Vol. 10, No. 12

Pluripotent stem cells (PSCs) can undergo unlimited selfrenewal and differentiate into all functional cell types of the human body. Adult stem cells such as hematopoietic stem cells are capable of life-long self-renewal and the reconstitution of an entire hematopoietic system. Therefore, stem cells are promising renewable source of functional cells for human cell therapy. In addition, the combination of PSCs and gene editing technology provides an important platform for modeling complex human diseases. However, the development of stem cell-based therapy faces many challenges, including genomic instability and immunogenicity. Overcoming these challenges will greatly facilitate the development of effective and safe stem cell based therapy for many currently incurable human diseases.
Tonghua Liu: A life dedicated to clinical pathology
Lin Dong, Tanping Fu, Junyi Pang, Zhiyong Liang, Wenli Duan
2019, 10(12): 857-860. doi: 10.1007/s13238-018-0601-0
FBXW7 E3 ubiquitin ligase: degrading, not degrading, or being degraded
Huiyin Lan, Yi Sun
2019, 10(12): 861-863. doi: 10.1007/s13238-019-0652-x
JMJD3 in the regulation of human diseases
Xiangxian Zhang, Li Liu, Xia Yuan, Yuquan Wei, Xiawei Wei
2019, 10(12): 864-882. doi: 10.1007/s13238-019-0653-9
In recent years, many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases. The Jumonji domain-containing protein D3 (JMJD3), specifically demethylate di- and trimethyllysine 27 on histone H3 (H3K27me2/3), has been widely studied in immune diseases, infectious diseases, cancer, developmental diseases, and aging related diseases. We will focus on the recent advances of JMJD3 function in human diseases, and looks ahead to the future of JMJD3 gene research in this review.
Research article
Core transcriptional signatures of phase change in the migratory locust
Pengcheng Yang, Li Hou, Xianhui Wang, Le Kang
2019, 10(12): 883-901. doi: 10.1007/s13238-019-0648-6
Phenotypic plasticity plays fundamental roles in successful adaptation of animals in response to environmental variations. Here, to reveal the transcriptome reprogramming in locust phase change, a typical phenotypic plasticity, we conducted a comprehensive analysis of multiple phase-related transcriptomic datasets of the migratory locust. We defined PhaseCore genes according to their contribution to phase differentiation by the adjustment for confounding principal components analysis algorithm (AC-PCA). Compared with other genes, PhaseCore genes predicted phase status with over 87.5% accuracy and displayed more unique gene attributes including the faster evolution rate, higher CpG content and higher specific expression level. Then, we identified 20 transcription factors (TFs) named PhaseCoreTF genes that are associated with the regulation of PhaseCore genes. Finally, we experimentally verified the regulatory roles of three representative TFs (Hr4, Hr46, and grh) in phase change by RNAi. Our findings revealed that core transcriptional signatures are involved in the global regulation of locust phase changes, suggesting a potential common mechanism underlying phenotypic plasticity in insects. The expression and network data are accessible in an online resource called LocustMine (http://www.locustmine.org:8080/locustmine).
Continuous culture of urine-derived bladder cancer cells for precision medicine
Shuai Jiang, Jiaqi Wang, Chen Yang, Renke Tan, Jun Hou, Yuan Shi, Huihui Zhang, Shiyu Ma, Jianan Wang, Mengmeng Zhang, George Philips, Zengxia Li, Jian Ma, Wanjun Yu, Guohua Wang, Yuanming Wu, Richard Schlegel, Huina Wang, Shanbo Cao, Jianming Guo, Xuefeng Liu, Yongjun Dang
2019, 10(12): 902-907. doi: 10.1007/s13238-019-0649-5
Ubiquitin is double-phosphorylated by PINK1 for enhanced pH-sensitivity of conformational switch
Shang-Xiang Ye, Zhou Gong, Ju Yang, Yu-Xin An, Zhu Liu, Qun Zhao, Ewen Lescop, Xu Dong, Chun Tang
2019, 10(12): 908-913. doi: 10.1007/s13238-019-0644-x
Genetic evidence for asymmetric blocking of higher-order chromatin structure by CTCF/cohesin
Yujia Lu, Jia Shou, Zhilian Jia, Yonghu Wu, Jinhuan Li, Ya Guo, Qiang Wu
2019, 10(12): 914-920. doi: 10.1007/s13238-019-00656-y
Lipid droplets and mitochondria are anchored during brown adipocyte differentiation
Liujuan Cui, Mirza Ahmed Hammad, Shuyan Zhang, Bin Liang, Pingsheng Liu
2019, 10(12): 921-926. doi: 10.1007/s13238-019-00661-1
Correction to: Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers
Yuanlong Ge, Shu Wu, Zepeng Zhang, Xiaocui Li, Feng Li, Siyu Yan, Haiying Liu, Junjiu Huang, Yong Zhao
2019, 10(12): 927-928. doi: 10.1007/s13238-019-0640-1