2020 Vol. 11, No. 1
Pluripotent stem cells (PSCs) can undergo unlimited self-renewal and differentiate into all functional cell types of the human body. Adult stem cells such as hematopoietic stem cells are capable of life-long self-renewal and the reconstitution of an entire hematopoietic system. Therefore, stem cells are promising renewable source of functional cells for human cell therapy. In addition, the combination of PSCs and gene editing technology provides an important platform for modeling complex human diseases. However, the development of stem cell-based therapy faces many challenges, including genomic instability and immunogenicity. Overcoming these challenges will greatly facilitate the development of effective and safe stem cell based therapy for many currently incurable human diseases.