2020 Vol. 11, No. 12
TRIM35, TRAF3, and PB2 of influenza A virus (IAV) form a circuit in which two means are employed by TRIM35 to defend the host against IAV infection. TRIM35 is a positive regulator of RIG-I-mediated innate immunity, leading to enhanced production of type I interferon by facilitating K63-linked polyubiquitination of TRAF3. Although IAV PB2 prevents K63-linked polyubiquitination of TRAF3, TRIM35 directly mediates K48-linked polyubiquitination and degradation of IAV PB2.