2022 Vol. 13, No. 3
Zn2+ is required for the activity of many mitochondrial proteins, which regulate mitochondrial dynamics, apoptosis and mitophagy. In this issue, Ma et al. utilize powerful genetic approaches in Caenorhabditis elegans to uncover evolutionarily conserved mitochondrial exporters and importers that control mitochondrial Zn2+ levels. They provide molecular insights into the mechanisms that control appropriate mitochondrial Zn2+ levels required for maintenance of mitochondrial homeostasis. The cover image shows that reinforced expression of human SLC25A25 (EGFP-SLC25A25, green), a mitochondrial Zn2+ importer, induced abnormally enlarged mitochondria (Mito Tracker DR staining, red) by elevating mitochondrial Zn2+ in HeLa cells.