Volume 1 Issue 9
Sep.  2010
Turn off MathJax
Article Contents
Xuelian Luo. Snapshots of a hybrid transcription factor in the Hippo pathway[J]. Protein&Cell, 2010, 1(9): 811-819. doi: 10.1007/s13238-010-0105-z
Citation: Xuelian Luo. Snapshots of a hybrid transcription factor in the Hippo pathway[J]. Protein&Cell, 2010, 1(9): 811-819. doi: 10.1007/s13238-010-0105-z

Snapshots of a hybrid transcription factor in the Hippo pathway

doi: 10.1007/s13238-010-0105-z
Funds:

The author thanks Hongtao Yu for critical reading of the manuscript. This work was supported by grant from the National Institutes of Health (to X.L. #GM085004).

  • Received Date: 2010-07-30
  • Rev Recd Date: 2010-08-16
  • The Hippo pathway plays key roles in animal development. It suppresses tumorigenesis by controlling the transcription of the target genes that are critical for cell proliferation and apoptosis. The transcriptional coactivator YAP is the major downstream effector of the Hippo signaling. Upon extracellular stimulation, a kinase cascade in the Hippo pathway phosphorylates YAP and promotes its cytoplasmic sequestration by 14-3-3 and ubiquitin-dependent degradation. When the Hippo pathway is turned off, YAP (which lacks a DNA-binding domain) is dephosphorylated and translocates to the nucleus, where it associates with the transcription factor TEAD to form a functional heterodimeric transcription factor and to promote the expression of the Hipporesponsive genes. Recently, structures of the YAPbinding domain of TEAD alone or in complex with YAP have revealed the atomic details of the TEAD-YAP interaction. Here, I review these exciting advances, propose a strategy for targeting the TEAD-YAP interaction using small molecules, and suggest potential mechanisms by which phosphorylation and 14-3-3 binding regulate the cytoplasmic retention of YAP.
  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (148) PDF downloads(254) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return