Volume 1 Issue 9
Sep.  2010
Turn off MathJax
Article Contents
Yide Mei, Aaron Stonestrom, Ya-Ming Hou, Xiaolu Yang. Apoptotic regulation and tRNA[J]. Protein&Cell, 2010, 1(9): 795-801. doi: 10.1007/s13238-010-0107-x
Citation: Yide Mei, Aaron Stonestrom, Ya-Ming Hou, Xiaolu Yang. Apoptotic regulation and tRNA[J]. Protein&Cell, 2010, 1(9): 795-801. doi: 10.1007/s13238-010-0107-x

Apoptotic regulation and tRNA

doi: 10.1007/s13238-010-0107-x
Funds:

The work is supported by NIH grants GM60911 and CA088868 to X.Y. and GM68561 and GM81601 to Y.-M. H.

  • Received Date: 2010-08-19
  • Rev Recd Date: 2010-08-26
  • Apoptotic regulation is critical to organismal homeostasis and protection against many human disease processes such as cancer. Significant research efforts over the past several decades have illuminated many signaling molecules and effecter proteins responsible for this form of programmed cell death. Recent evidence suggests that transfer RNA (tRNA) regulates apoptotic sensitivity at the level of cytochrome c-mediated apoptosome formation. This finding unexpectedly places tRNA at the nexus of cellular biosynthesis and survival. Here we review the current understanding of both the apoptotic machinery and tRNA biology. We describe the evidence linking tRNA and cytochrome c in depth, and speculate on the implications of this link in cell biology.
  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (246) PDF downloads(105) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return