Volume 2 Issue 6
Jun.  2011
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Jiwei Ding, Lishan Su, Guangxia Gao. Hrs inhibits citron kinase-mediated HIV-1 budding via its FYVE domain[J]. Protein&Cell, 2011, 2(6): 470-476. doi: 10.1007/s13238-011-1053-y
Citation: Jiwei Ding, Lishan Su, Guangxia Gao. Hrs inhibits citron kinase-mediated HIV-1 budding via its FYVE domain[J]. Protein&Cell, 2011, 2(6): 470-476. doi: 10.1007/s13238-011-1053-y

Hrs inhibits citron kinase-mediated HIV-1 budding via its FYVE domain

doi: 10.1007/s13238-011-1053-y
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This work was in part supported by grants to Guangxia Gao from the National Natural Science Foundation of China (Grant No. 81030030) and from the Ministry of Science and Technology of China (No. 2009zx09501-029).

  • Received Date: 2011-04-08
  • Rev Recd Date: 2011-05-12
  • Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is a key component of the endosomal sorting complexes required for transport and has been demonstrated to play a regulatory role in endocytosis/exocytosis and the accumulation of internal vesicles in multivesicular bodies. Citron kinase is a Ser/The kinase that we previously reported to enhance human immunodeficiency virus type 1 (HIV-1) virion production. However, the relationship between Hrs and citron kinase in HIV-1 production remains elusive. Here, we report that Hrs interacts with citron kinase via its FYVE domain. Overexpression of Hrs or the FYVE domain resulted in a significant decrease in HIV-1 virion production. Depletion of Hrs by RNA interference in HEK293T cells increased HIV-1 virion production and enhanced the activity of citron kinase. These data suggest that Hrs inhibits HIV-1 production by inhibiting citron kinase-mediated exocytosis.
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