Volume 3 Issue 12
Dec.  2012
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Yuna Sun, Yu Guo, Zhiyong Lou. A versatile building block: the structures and functions of negative-sense single-stranded RNA virus nucleocapsid proteins[J]. Protein&Cell, 2012, 3(12): 893-902. doi: 10.1007/s13238-012-2087-5
Citation: Yuna Sun, Yu Guo, Zhiyong Lou. A versatile building block: the structures and functions of negative-sense single-stranded RNA virus nucleocapsid proteins[J]. Protein&Cell, 2012, 3(12): 893-902. doi: 10.1007/s13238-012-2087-5

A versatile building block: the structures and functions of negative-sense single-stranded RNA virus nucleocapsid proteins

doi: 10.1007/s13238-012-2087-5
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This work was supported by the National Natural Science Foundation of China (Grant Nos. 31000332 and 31170678) and the Fundamental Research Funds for the Central Universities.

  • Received Date: 2012-08-22
  • Rev Recd Date: 2012-09-03
  • Nucleocapsid protein (NPs) of negative-sense singlestranded RNA (-ssRNA) viruses function in different stages of viral replication, transcription, and maturation. Structural investigations show that -ssRNA viruses that encode NPs preliminarily serve as structural building blocks that encapsidate and protect the viral genomic RNA and mediate the interaction between genomic RNA and RNA-dependent RNA polymerase. However, recent structural results have revealed other biological functions of -ssRNA viruses that extend our understanding of the versatile roles of virally encoded NPs.
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