Volume 4 Issue 2
Feb.  2013
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Wensu Liu, Ming Li, Jing Qu, Fei Yi, Guang-Hui Liu. Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism[J]. Protein&Cell, 2013, 4(2): 83-85. doi: 10.1007/s13238-012-2940-6
Citation: Wensu Liu, Ming Li, Jing Qu, Fei Yi, Guang-Hui Liu. Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism[J]. Protein&Cell, 2013, 4(2): 83-85. doi: 10.1007/s13238-012-2940-6

Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism

doi: 10.1007/s13238-012-2940-6
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This work is supported by the Thousand Young Talents program of China, the National Laboratory of Biomacromolecules, the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA01020312), and National Natural Science Foundation of China (Grant Nos. 81271266, 31222039 and 31201111).

  • Recent studies have been raising doubts on the safety of induced pluripotent stem cells (iPSCs) and proposing that the process of reprogramming brought about copy number variations (CNVs) in iPSCs. However, a recent paper published in Nature provided evidence showing that most CNVs were pre-existed as somatic mosaicism but not resulted from the reprogramming. This new finding would profoundly reshape some previous thoughts and endorse the confidence of iPSCs in both research and therapy.
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