Volume 4 Issue 8
Aug.  2013
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Xin Mu, Wei Li, Xinlu Wang, Guangxia Gao. YB-1 stabilizes HIV-1 genomic RNA and enhances viral production[J]. Protein&Cell, 2013, 4(8): 591-597. doi: 10.1007/s13238-013-3011-3
Citation: Xin Mu, Wei Li, Xinlu Wang, Guangxia Gao. YB-1 stabilizes HIV-1 genomic RNA and enhances viral production[J]. Protein&Cell, 2013, 4(8): 591-597. doi: 10.1007/s13238-013-3011-3

YB-1 stabilizes HIV-1 genomic RNA and enhances viral production

doi: 10.1007/s13238-013-3011-3
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This work was supported in part by Grants to G.G. from National Natural Science Foundation of China (Grant No. 81030030) and the National Basic Research Program (973 Program) (No. 2012CB910203).

  • HIV-1 utilizes cellular factors for efficient replication. The viral RNA is different from cellular mRNAs in many aspects, and is prone to attacks by cellular RNA quality control systems. To establish effective infection, the virus has evolved multiple mechanisms to protect its RNA. Here, we show that expression of the Y-box binding protein 1 (YB-1) enhanced the production of HIV-1. Downregulation of endogenous YB-1 in producer cells decreased viral production. YB-1 increased viral protein expression by stabilizing HIV-1 RNAs. The stem loop 2 in the HIV-1 RNA packaging signal was mapped to be the YB-1-responsive element. Taken together, these results indicate that YB-1 stabilizes HIV-1 genomic RNA and thereby enhances HIV-1 gene expression and viral production.
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