Volume 4 Issue 11
Nov.  2013
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Tengteng Zhang, Yun Xia, Lijuan Zhang, Wanrong Bao, Chao Hong, Xiao-Ming Gao. CD1dhiCD5+ B cells differentiate into antibody-secreting cells under the stimulation with calreticulin fragment[J]. Protein&Cell, 2013, 4(11): 872-881. doi: 10.1007/s13238-013-3062-5
Citation: Tengteng Zhang, Yun Xia, Lijuan Zhang, Wanrong Bao, Chao Hong, Xiao-Ming Gao. CD1dhiCD5+ B cells differentiate into antibody-secreting cells under the stimulation with calreticulin fragment[J]. Protein&Cell, 2013, 4(11): 872-881. doi: 10.1007/s13238-013-3062-5

CD1dhiCD5+ B cells differentiate into antibody-secreting cells under the stimulation with calreticulin fragment

doi: 10.1007/s13238-013-3062-5
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This study was supported by grants from PCSIRT (IRT1075), the National Natural Science Foundation of China (Grant Nos. 31370908, 31070781, and 31100633), the National Basic Research Program (973 Program) (No. 2010CB529102), and Foundation of Nature Science of Jiangsu Higher Education Institutions of China (11KJB180011).

  • Received Date: 2013-07-16
  • Rev Recd Date: 2013-10-11
  • Calreticulin (CRT) is a multifunctional molecule in both intracellular and extracellular environment. We have previously found that a recombinant CRT fragment (rCRT/39-272) could modulate T cell-mediated immunity in mice via activation and expansion of CD1dhiCD5+ B cells as well as induction of CRT-specific regulatory antibodies. Antibody secreting cells (ASCs) are terminally differentiated B cells responsible for producing antibodies to participate in positive immune response as well as immune regulation. In this study, we demonstrate that rCRT/39-272 differentiates murine CD1dhiCD5+ B cells into ASCs marked by increased expression of plasma cell-associated transcription factors and production of polyreactive antibodies against DNA and CRT in vitro. Intraperitoneal administration of rCRT/39-272 augmented differentiation of CD1dhiCD5+ B cells into ASCs in naïve mice or mice with experimental autoimmune encephalomyelitis. Thus, we propose that ASC differentiation and subsequent antibody production of CD1dhiCD5+ B cells are key steps in CRT-mediated immunoregulation on inflammatory T cell responses.
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