Volume 5 Issue 3
Mar.  2014
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Xiaomin Song, Sheng Wang, Lin Li. New insights into the regulation of Axin function in canonical Wnt signaling pathway[J]. Protein&Cell, 2014, 5(3): 186-193. doi: 10.1007/s13238-014-0019-2
Citation: Xiaomin Song, Sheng Wang, Lin Li. New insights into the regulation of Axin function in canonical Wnt signaling pathway[J]. Protein&Cell, 2014, 5(3): 186-193. doi: 10.1007/s13238-014-0019-2

New insights into the regulation of Axin function in canonical Wnt signaling pathway

doi: 10.1007/s13238-014-0019-2
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L.L and X.S would like to thank the National Basic Research Program (973 Program) (Nos. 2010CB912100 to L.L, and 2011CD966300 to X.S) and the National Natural Science Foundation of China (Grant Nos. 31230044, 30930052 and 91213304 to L.L, and 31100532 to X.S). X.S. gratefully acknowledges the support of SA-SIBS scholarship program.

  • Received Date: 2013-11-09
  • Rev Recd Date: 2013-12-10
  • The Wnt signaling pathway plays crucial roles during embryonic development, whose aberration is implicated in a variety of human cancers. Axin, a key component of canonical Wnt pathway, plays dual roles in modulating Wnt signaling:on one hand, Axin scaffolds the "β-catenin destruction complex" to promote β-catenin degradation and therefore inhibits the Wnt signal transduction; on the other hand, Axin interacts with LRP5/6 and facilitates the recruitment of GSK3 to the plasma membrane to promote LRP5/6 phosphorylation and Wnt signaling. The differential assemblies of Axin with these two distinct complexes have to be tightly controlled for appropriate transduction of the "on" or "off" Wnt signal. So far, there are multiple mechanisms revealed in the regulation of Axin activity, such as posttranscriptional modulation, homo/hetero-polymerization and auto-inhibition. These mechanisms may work cooperatively to modulate the function of Axin, thereby playing an important role in controlling the canonical Wnt signaling. In this review, we will focus on the recent progresses regarding the regulation of Axin function in canonical Wnt signaling.
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