Volume 5 Issue 3
Mar.  2014
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Yan Huang, Puping Liang, Dan Liu, Junjiu Huang, Zhou Songyang. Telomere regulation in pluripotent stem cells[J]. Protein&Cell, 2014, 5(3): 194-202. doi: 10.1007/s13238-014-0028-1
Citation: Yan Huang, Puping Liang, Dan Liu, Junjiu Huang, Zhou Songyang. Telomere regulation in pluripotent stem cells[J]. Protein&Cell, 2014, 5(3): 194-202. doi: 10.1007/s13238-014-0028-1

Telomere regulation in pluripotent stem cells

doi: 10.1007/s13238-014-0028-1
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This study was supported by the National Basic Research Program (973 Program) (Nos. 2010CB945401 and 2012CB911201), the National Natural Science Foundation of China (Grant Nos. 31371508, 31000611 and 91019020), Introduced Innovative R&D Team of Guangdong Province (201001Y0104687244), Zhujiang Program of Science and Technology Nova in Guangzhou (2011J2200082) and "985" project foundation of Sun Yat-sen University (33000-3281303).

  • Received Date: 2014-01-12
  • Rev Recd Date: 2014-01-23
  • Pluripotent stem cells (PSCs) have the potential to produce any types of cells from all three basic germ layers and the capacity to self-renew and proliferate indefinitely in vitro. The two main types of PSCs, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), share common features such as colony morphology, high expression of Oct4 and Nanog, and strong alkaline phosphatase activity. In recent years, increasing evidences suggest that telomere length represents another important internal factor in maintaining stem cell pluripotency. Telomere length homeostasis and its structural integrity help to protect chromosome ends from recombination, end fusion, and DNA damage responses, ensuring the divisional ability of mammalian cells. PSCs generally exhibit high telomerase activity to maintain their extremely long and stable telomeres, and emerging data indicate the alternative lengthening of telomeres (ALT) pathway may play an important role in telomere functions too. Such characteristics are likely key to their abilities to differentiate into diverse cell types in vivo. In this review, we will focus on the function and regulation of telomeres in ESCs and iPSCs, thereby shedding light on the importance of telomere length to pluripotency and the mechanisms that regulate telomeres in PSCs.
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