Volume 5 Issue 8
Aug.  2014
Turn off MathJax
Article Contents
Peng Jiang, Wenjing Du, Mian Wu. Regulation of the pentose phosphate pathway in cancer[J]. Protein&Cell, 2014, 5(8): 592-602. doi: 10.1007/s13238-014-0082-8
Citation: Peng Jiang, Wenjing Du, Mian Wu. Regulation of the pentose phosphate pathway in cancer[J]. Protein&Cell, 2014, 5(8): 592-602. doi: 10.1007/s13238-014-0082-8

Regulation of the pentose phosphate pathway in cancer

doi: 10.1007/s13238-014-0082-8
Funds:

We apologize to those authors whose excellent work could not be cited due to space constraints. This work was supported by the Start-Up Package Fund from Tsinghua University to J.P. and the grant (Grants No. 2010CB912804 and 31030046 to WM) from National Natural Science Foundation of China.

  • Received Date: 2014-04-07
  • Rev Recd Date: 2014-05-22
  • Energy metabolism is significantly reprogrammed in many human cancers, and these alterations confer many advantages to cancer cells, including the promotion of biosynthesis, ATP generation, detoxification and support of rapid proliferation. The pentose phosphate pathway (PPP) is a major pathway for glucose catabolism. The PPP directs glucose flux to its oxidative branch and produces a reduced form of nicotinamide adenine dinucleotide phosphate (NADPH), an essential reductant in anabolic processes. It has become clear that the PPP plays a critical role in regulating cancer cell growth by supplying cells with not only ribose-5-phosphate but also NADPH for detoxification of intracellular reactive oxygen species, reductive biosynthesis and ribose biogenesis. Thus, alteration of the PPP contributes directly to cell proliferation, survival and senescence. Furthermore, recent studies have shown that the PPP is regulated oncogenically and/or metabolically by numerous factors, including tumor suppressors, oncoproteins and intracellular metabolites. Dysregulation of PPP flux dramatically impacts cancer growth and survival. Therefore, a better understanding of how the PPP is reprogrammed and the mechanism underlying the balance between glycolysis and PPP flux in cancer will be valuable in developing therapeutic strategies targeting this pathway.
  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (415) PDF downloads(4329) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return