Volume 6 Issue 4
Apr.  2015
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Jun Cao, Zhengyu Luo, Qingyu Cheng, Qianlan Xu, Yan Zhang, Fei Wang, Yan Wu, Xiaoyuan Song. Three-dimensional regulation of transcription[J]. Protein&Cell, 2015, 6(4): 241-253. doi: 10.1007/s13238-015-0135-7
Citation: Jun Cao, Zhengyu Luo, Qingyu Cheng, Qianlan Xu, Yan Zhang, Fei Wang, Yan Wu, Xiaoyuan Song. Three-dimensional regulation of transcription[J]. Protein&Cell, 2015, 6(4): 241-253. doi: 10.1007/s13238-015-0135-7

Three-dimensional regulation of transcription

doi: 10.1007/s13238-015-0135-7
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This work was supported by grants from the National Natural Science Foundation of China (Grant No. 31472059), the National Key Scientific Program of China (No. 2015CB943000), the Fundamental Research Funds for the Central Universities (WK2070000034, WK2070000023) and the Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology (2014FXCX009) to XYS. XYS is a recipient of the Young Thousand Talents program (KJ2070000026).

  • Received Date: 2014-12-25
  • Rev Recd Date: 2015-01-09
  • Cells can adapt to environment and development by reconstructing their transcriptional networks to regulate diverse cellular processes without altering the underlying DNA sequences. These alterations, namely epigenetic changes, occur during cell division, differentiation and cell death. Numerous evidences demonstrate that epigenetic changes are governed by various types of determinants, including DNA methylation patterns, histone posttranslational modification signatures, histone variants, chromatin remodeling, and recently discovered chromosome conformation characteristics and noncoding RNAs (ncRNAs). Here, we highlight recent efforts on how the two latter epigenetic factors participate in the sophisticated transcriptional process and describe emerging techniques which permit us to uncover and gain insights into the fascinating genomic regulation.
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