Volume 6 Issue 4
Apr.  2015
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Yufei Yang, Mo Hu, Kaiwen Yu, Xiangmei Zeng, Xiaoyun Liu. Mass spectrometry-based proteomic approaches to study pathogenic bacteria-host interactions[J]. Protein&Cell, 2015, 6(4): 265-274. doi: 10.1007/s13238-015-0136-6
Citation: Yufei Yang, Mo Hu, Kaiwen Yu, Xiangmei Zeng, Xiaoyun Liu. Mass spectrometry-based proteomic approaches to study pathogenic bacteria-host interactions[J]. Protein&Cell, 2015, 6(4): 265-274. doi: 10.1007/s13238-015-0136-6

Mass spectrometry-based proteomic approaches to study pathogenic bacteria-host interactions

doi: 10.1007/s13238-015-0136-6
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The work in the group was supported by grants from Peking University, the Thousand Young Talents program of Chinese government and National Natural Science Foundation of China (Grant Nos. 21305006 and 21475005).

  • Received Date: 2014-12-25
  • Rev Recd Date: 2015-01-21
  • Elucidation of molecular mechanisms underlying hostpathogen interactions is important for control and treatment of infectious diseases worldwide. Within the last decade, mass spectrometry (MS)-based proteomics has become a powerful and effective approach to better understand complex and dynamic host-pathogen interactions at the protein level. Herein we will review the recent progress in proteomic analyses towards bacterial infection of their mammalian host with a particular focus on enteric pathogens. Large-scale studies of dynamic proteomic alterations during infection will be discussed from the perspective of both pathogenic bacteria and host cells.
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