Volume 6 Issue 4
Apr.  2015
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Haisheng Yu, Peng Zhang, Xiangyun Yin, Zhao Yin, Quanxing Shi, Ya Cui, Guanyuan Liu, Shouli Wang, Pier Paolo Piccaluga, Taijiao Jiang, Liguo Zhang. Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset[J]. Protein&Cell, 2015, 6(4): 297-306. doi: 10.1007/s13238-015-0140-x
Citation: Haisheng Yu, Peng Zhang, Xiangyun Yin, Zhao Yin, Quanxing Shi, Ya Cui, Guanyuan Liu, Shouli Wang, Pier Paolo Piccaluga, Taijiao Jiang, Liguo Zhang. Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset[J]. Protein&Cell, 2015, 6(4): 297-306. doi: 10.1007/s13238-015-0140-x

Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset

doi: 10.1007/s13238-015-0140-x
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This work was supported by grants from Beijing Municipal Science & Technology Commission (SCW 2014-09), Chinese Academy of Science (KJZD-EW-L10-02) and Ministry of Health (2013ZX10001002) to L.Z.

  • Received Date: 2014-12-10
  • Rev Recd Date: 2014-12-25
  • Dendritic cells (DCs) comprise two functionally distinct subsets:plasmacytoid DCs (pDCs) and myeloid DCs (mDCs). pDCs are specialized in rapid and massive secretion of type I interferon (IFN-I) in response to nucleic acids through Toll like receptor (TLR)-7 or TLR-9. In this report, we characterized a CD56+ DC population that express typical pDC markers including CD123 and BDCA2 but produce much less IFN-I comparing with pDCs. In addition, CD56+ DCs cluster together with mDCs but not pDCs by genome-wide transcriptional profiling. Accordingly, CD56+ DCs functionally resemble mDCs by producing IL-12 upon TLR4 stimulation and priming naïve T cells without prior activation. These data suggest that the CD56+ DCs represent a novel mDC subset mixed with some pDC features. A CD4+CD56+ hematological malignancy was classified as blastic plasmacytoid dendritic cell neoplasm (BPDCN) due to its expression of characteristic molecules of pDCs. However, we demonstrated that BPDCN is closer to CD56+ DCs than pDCs by global gene-expression profiling. Thus, we propose that the CD4+CD56+ neoplasm may be a tumor counterpart of CD56+ mDCs but not pDCs.
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