Volume 6 Issue 8
Aug.  2015
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Long Lin, Yuping Li, Libo Yan, Gangming Zhang, Yu Zhao, Hong Zhang. LSY-2 is essential for maintaining the germ-soma distinction in C. elegans[J]. Protein&Cell, 2015, 6(8): 599-609. doi: 10.1007/s13238-015-0173-1
Citation: Long Lin, Yuping Li, Libo Yan, Gangming Zhang, Yu Zhao, Hong Zhang. LSY-2 is essential for maintaining the germ-soma distinction in C. elegans[J]. Protein&Cell, 2015, 6(8): 599-609. doi: 10.1007/s13238-015-0173-1

LSY-2 is essential for maintaining the germ-soma distinction in C. elegans

doi: 10.1007/s13238-015-0173-1
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This work was supported by the National Basic Research Program (973 Program) (Nos. 2013CB910100 and 2011CB910100) and the National Natural Science Foundation of China (Grant Nos. 31421002 and 31225018) to H.Z, The research of Hong Zhang was supported in part by an International Early Career Scientist grant from the Howard Hughes Medical Institute.

  • Received Date: 2015-02-02
  • Rev Recd Date: 2015-05-14
  • The mechanisms that specify and maintain the characteristics of germ cells during animal development are poorly understood. In this study, we demonstrated that loss of function of the zinc-finger gene lsy-2 results in various somatic cells adopting germ cells characteristics, including expression of germline-specific P granules, enhanced RNAi activity and transgene silencing. The soma to germ transformation in lsy-2 mutants requires the activities of multiple chromatin remodeling complexes, including the MES-4 complex and the ISW-1 complex. The distinct germline-specific features in somatic cells and the gene expression profile indicate that lsy-2 acts in the Mec complex in this process. Our study demonstrated that lsy-2 functions in the maintenance of the soma-germ distinction.
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