Volume 6 Issue 8
Aug.  2015
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Qianqian Liang, Chen Xu, Xinyun Chen, Xiuya Li, Chao Lu, Ping Zhou, Lianhua Yin, Ruizhe Qian, Sifeng Chen, Zhendong Ling, Ning Sun. The roles of Mesp family proteins: functional diversity and redundancy in differentiation of pluripotent stem cells and mammalian mesodermal development[J]. Protein&Cell, 2015, 6(8): 553-561. doi: 10.1007/s13238-015-0176-y
Citation: Qianqian Liang, Chen Xu, Xinyun Chen, Xiuya Li, Chao Lu, Ping Zhou, Lianhua Yin, Ruizhe Qian, Sifeng Chen, Zhendong Ling, Ning Sun. The roles of Mesp family proteins: functional diversity and redundancy in differentiation of pluripotent stem cells and mammalian mesodermal development[J]. Protein&Cell, 2015, 6(8): 553-561. doi: 10.1007/s13238-015-0176-y

The roles of Mesp family proteins: functional diversity and redundancy in differentiation of pluripotent stem cells and mammalian mesodermal development

doi: 10.1007/s13238-015-0176-y
Funds:

This work was supported by the National Natural Science Foundation of China (Grant No. 81322003) (N.S.)

the Recruitment Program of Global Experts of the Organization Department of the Central Committee of the CPC (N.S.)

and the Science and Technology Commission of Shanghai Municipality (No. 13JC1401704) (N.S.).

  • Received Date: 2015-03-19
  • Rev Recd Date: 2015-05-03
  • Mesp family proteins comprise two members named mesodermal posterior 1 (Mesp1) and mesodermal posterior 2 (Mesp2). Both Mesp1 and Mesp2 are transcription factors and they share an almost identical basic helix-loop-helix motif. They have been shown to play critical regulating roles in mammalian heart and somite development. Mesp1 sits in the core of the complicated regulatory network for generation of cardiovascular progenitors while Mesp2 is central for somitogenesis. Here we summarize the similarities and differences in their molecular functions during mammalian early mesodermal development and discuss possible future research directions for further study of the functions of Mesp1 and Mesp2. A comprehensive knowledge of molecular functions of Mesp family proteins will eventually help us better understand mammalian heart development and somitogenesis as well as improve the production of specific cell types from pluripotent stem cells for future regenerative therapies.
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