Volume 7 Issue 2
Feb.  2016
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Hosuk Lee, Sungwook Han, Chang Seob Kwon, Daeyoup Lee. Biogenesis and regulation of the let-7 miRNAs and their functional implications[J]. Protein&Cell, 2016, 7(2): 100-113. doi: 10.1007/s13238-015-0212-y
Citation: Hosuk Lee, Sungwook Han, Chang Seob Kwon, Daeyoup Lee. Biogenesis and regulation of the let-7 miRNAs and their functional implications[J]. Protein&Cell, 2016, 7(2): 100-113. doi: 10.1007/s13238-015-0212-y

Biogenesis and regulation of the let-7 miRNAs and their functional implications

doi: 10.1007/s13238-015-0212-y
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This work was supported by grants from the Stem Cell Research Program (2012M 3A9B 4027953) and the KAIST Future Systems Healthcare Project funded by the Ministry of Science, ICTand Future Planning.

  • Received Date: 2015-07-15
  • Rev Recd Date: 2015-08-17
  • The let-7 miRNAwas one of thefirst miRNAs discovered in the nematode, Caenorhabditis elegans, and its biological functions show a high level of evolutionary conservation from the nematode to the human. Unlike in C. elegans, higher animals have multiple isoforms of let-7 miRNAs; these isoforms share a consensus sequence called the ‘seed sequence’ and these isoforms are categorized into let-7 miRNA family. The expression of let-7 family is required for developmental timing and tumor suppressor function, but must be suppressed for the self-renewal of stem cells. Therefore, let-7 miRNA biogenesis must be carefully controlled. To generate a let-7 miRNA, a primary transcript is produced by RNA polymerase Ⅱ and then subsequently processed by Drosha/DGCR8, TUTase, and Dicer. Because dysregulation of let-7 processing is deleterious, biogenesis of let-7 is tightly regulated by cellular factors, such as the RNA binding proteins, LIN28A/B and DIS3L2. In this review, we discuss the biological functions and biogenesis of let-7 miRNAs, focusing on the molecular mechanisms of regulation of let-7 biogenesis in vertebrates, such as the mouse and the human.
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