Volume 7 Issue 2
Feb.  2016
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Haiyang Zhang, Jingjing Duan, Yanjun Qu, Ting Deng, Rui Liu, Le Zhang, Ming Bai, Jialu Li, Tao Ning, Shaohua Ge, Xia Wang, Zhenzhen Wang, Qian Fan, Hongli Li, Guoguang Ying, Dingzhi Huang, Yi Ba. Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer[J]. Protein&Cell, 2016, 7(2): 141-151. doi: 10.1007/s13238-015-0234-5
Citation: Haiyang Zhang, Jingjing Duan, Yanjun Qu, Ting Deng, Rui Liu, Le Zhang, Ming Bai, Jialu Li, Tao Ning, Shaohua Ge, Xia Wang, Zhenzhen Wang, Qian Fan, Hongli Li, Guoguang Ying, Dingzhi Huang, Yi Ba. Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer[J]. Protein&Cell, 2016, 7(2): 141-151. doi: 10.1007/s13238-015-0234-5

Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer

doi: 10.1007/s13238-015-0234-5
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This work was supported by grants from the National research platform of clinical evaluation technology for new anticancer drugs (No. 2013ZX09303001), the National Natural Science Foundation of China (Grant Nos. 81201946 and 81372394) and Tianjin City High School Science & Technology Fund Planning Project (20130122).

  • Received Date: 2015-09-30
  • Rev Recd Date: 2015-11-19
  • Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator of the intrinsic apoptotic cascade and mediates cell apoptosis. Although miRNAs have been reported to be involved in each stage of cancer development, the role of miR-24 in GC has not been reported yet. In the present study, miR-24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of GC. Studies from both in vitro and in vivo shown that miR-24 regulates BCL2L11 expression by directly binding with 3'UTR of mRNA, thus promoting cell growth, migration while inhibiting cell apoptosis. Therefore, miR-24 is a novel onco-miRNA that can be potential drug targets for future clinical use.
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