Volume 8 Issue 8
Aug.  2017
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Hua Li, Yangbing Zhao. Increasing the safety and efficacy of chimeric antigen receptor T cell therapy[J]. Protein&Cell, 2017, 8(8): 573-589. doi: 10.1007/s13238-017-0411-9
Citation: Hua Li, Yangbing Zhao. Increasing the safety and efficacy of chimeric antigen receptor T cell therapy[J]. Protein&Cell, 2017, 8(8): 573-589. doi: 10.1007/s13238-017-0411-9

Increasing the safety and efficacy of chimeric antigen receptor T cell therapy

doi: 10.1007/s13238-017-0411-9
  • Received Date: 2017-02-16
  • Rev Recd Date: 2017-04-07
  • Chimeric antigen receptor (CAR) T cell therapy is a promising cancer treatment that has recently been undergoing rapid development. However, there are still some major challenges, including precise tumor targeting to avoid off-target or "on-target/off-tumor" toxicity, adequate T cell infiltration and migration to solid tumors and T cell proliferation and persistence across the physical and biochemical barriers of solid tumors. In this review, we focus on the primary challenges and strategies to design safe and effective CAR T cells, including using novel cutting-edge technologies for CAR and vector designs to increase both the safety and efficacy, further T cell modification to overcome the tumorassociated immune suppression, and using gene editing technologies to generate universal CAR T cells. All these efforts promote the development and evolution of CAR T cell therapy and move toward our ultimate goal-curing cancer with high safety, high efficacy, and low cost.
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