Volume 10 Issue 4
Apr.  2019
Turn off MathJax
Article Contents
Xiang Zhang, Xiaoyu Li, Fei Ning, Yingli Shang, Xiaoyu Hu. TLE4 acts as a corepressor of Hes1 to inhibit inflammatory responses in macrophages[J]. Protein&Cell, 2019, 10(4): 300-305. doi: 10.1007/s13238-018-0554-3
Citation: Xiang Zhang, Xiaoyu Li, Fei Ning, Yingli Shang, Xiaoyu Hu. TLE4 acts as a corepressor of Hes1 to inhibit inflammatory responses in macrophages[J]. Protein&Cell, 2019, 10(4): 300-305. doi: 10.1007/s13238-018-0554-3

TLE4 acts as a corepressor of Hes1 to inhibit inflammatory responses in macrophages

doi: 10.1007/s13238-018-0554-3
Funds:

This research was supported by Ministry of Science and Technology of China National Key Research Projects 2015CB943200 (X. Hu), National Natural Science Foundation of China grants 31725010 (X. Hu), 81422019 (X. Hu), 81571580 (X. Hu), 91642115 (X. Hu) and 81661130161 (X. Hu), Shandong Provincial Natural Science Foundation of China grant ZR2017MC021 (Y. Shang), funds from Tsinghua-Peking Center for Life Sciences (X. Hu) and funds from Shandong "Double Top" Program 564013 (Y. Shang).

  • loading
  • [1]
    Buscarlet M, Stifani S (2007) The ‘Marx’ of Groucho on development and disease. Trends Cell Biol 17:353-361
    [2]
    Chen G, Courey AJ (2000) Groucho/TLE family proteins and transcriptional repression. Gene 249:1-16
    [3]
    Guo XK, Ou J, Liang S, Zhou X, Hu X (2018) Epithelial Hes1 maintains gut homeostasis by preventing microbial dysbiosis. Mucosal Immunol. https://doi.org/10.1038/mi.2017.111
    [4]
    Hu X, Chung AY, Wu I, Foldi J, Chen J, Ji JD, Tateya T, Kang YJ, Han J, Gessler M et al (2008) Integrated regulation of Toll-like receptor responses by Notch and Interferon-γ pathways. Immunity 29:691-703
    [5]
    Kishimoto T (2005) INTERLEUKIN-6:from basic science to medicine-40 years in immunology. Annu Rev Immunol 23:1-21
    [6]
    Kobayashi T, Kageyama R (2014) Expression dynamics and functions of Hes factors in development and diseases. In:Taneja R (ed) Current topics in developmental biology. Academic Press, New York, pp 263-283
    [7]
    Lyakh L, Trinchieri G, Provezza L, Carra G, Gerosa F (2008) Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans. Immunol Rev 226:112-131
    [8]
    Neurath MF (2014) Cytokines in inflammatory bowel disease. Nat Rev Immunol 14:329
    [9]
    Ramasamy S, Saez B, Mukhopadhyay S, Ding D, Ahmed AM, Chen X, Pucci F, Yamin R, Wang J, Pittet MJ et al (2016) Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-kappaB inflammatory pathway. Proc Natl Acad Sci USA 113:1871-1876
    [10]
    Shang Y, Coppo M, He T, Ning F, Yu L, Kang L, Zhang B, Ju C, Qiao Y, Zhao B et al (2016a) The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation. Nat Immunol 17:930-937
    [11]
    Shang Y, Smith S, Hu X (2016b) Role of Notch signaling in regulating innate immunity and inflammation in health and disease. Protein Cell 7:159-174
    [12]
    Staal FJ, Luis TC, Tiemessen MM (2008) WNT signalling in the immune system:WNT is spreading its wings. Nat Rev Immunol 8:581-593
    [13]
    Trinchieri G (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3:133-146
    [14]
    Ueo T, Imayoshi I, Kobayashi T, Ohtsuka T, Seno H, Nakase H, Chiba T, Kageyama R (2012) The role of Hes genes in intestinal development, homeostasis and tumor formation. Development 139:1071-1082
    [15]
    Wheat JC, Krause DS, Shin TH, Chen X, Wang J, Ding D, Yamin R, Sweetser DA (2014) The corepressor Tle4 is a novel regulator of murine hematopoiesis and bone development. PLoS ONE 9:e105557
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)

    Article Metrics

    Article views (633) PDF downloads(438) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return