Volume 10 Issue 6
Jun.  2019
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Xiaomeng An, Linlin Li, Sen Wu. In vivo tunable CRISPR mediates efficient somatic mutagenesis to generate tumor models[J]. Protein&Cell, 2019, 10(6): 450-454. doi: 10.1007/s13238-018-0579-7
Citation: Xiaomeng An, Linlin Li, Sen Wu. In vivo tunable CRISPR mediates efficient somatic mutagenesis to generate tumor models[J]. Protein&Cell, 2019, 10(6): 450-454. doi: 10.1007/s13238-018-0579-7

In vivo tunable CRISPR mediates efficient somatic mutagenesis to generate tumor models

doi: 10.1007/s13238-018-0579-7
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  • [1]
    Balboa D, Weltner J, Eurola S, Trokovic R, Wartiovaara K, Otonkoski T (2015) Conditionally stabilized dCas9 activator for controlling gene expression in human cell reprogramming and differentiation. Stem Cell Rep 5:448-459
    [2]
    Dow LE, Fisher J, O'Rourke KP, Muley A, Kastenhuber ER, Livshits G, Tschaharganeh DF, Socci ND, Lowe SW (2015) Inducible in vivo genome editing with CRISPR-Cas9. Nat Biotechnol 33:390-U398
    [3]
    Iwamoto M, Bjorklund T, Lundberg C, Kirik D, Wandless TJ (2010) A general chemical method to regulate protein stability in the mammalian central nervous system. Chem Biol 17:981-988
    [4]
    Kleinjan DA, Wardrope C, Nga Sou S, Rosser SJ (2017) Drugtunable multidimensional synthetic gene control using inducible degron-tagged dCas9 effectors. Nat Commun 8:1191
    [5]
    Konermann S, Brigham MD, Trevino AE, Hsu PD, Heidenreich M, Cong L, Platt RJ, Scott DA, Church GM, Zhang F (2013) Optical control of mammalian endogenous transcription and epigenetic states. Nature 500:472-476
    [6]
    Liu KI, Ramli MNB, Woo CWA, Wang YM, Zhao TY, Zhang XJ, Yim GRD, Chong BY, Gowher A, Chua MZH et al (2016) A chemicalinducible CRISPR-Cas9 system for rapid control of genome editing. Nat Chem Biol 12:980-987
    [7]
    Lu J, Zhao C, Zhao Y, Zhang J, Zhang Y, Chen L, Han Q, Ying Y, Peng S, Ai R et al (2018) Multimode drug inducible CRISPR/Cas9 devices for transcriptional activation and genome editing. Nucleic Acids Res 46:e25
    [8]
    Maji B, Moore CL, Zetsche B, Volz SE, Zhang F, Shoulders MD, Choudhary A (2017) Multidimensional chemical control of CRISPR-Cas9. Nat Chem Biol 13:9-11
    [9]
    Mali P, Yang LH, Esvelt KM, Aach J, Guell M, DiCarlo JE, Norville JE, Church GM (2013) RNA-guided human genome engineering via Cas9. Science 339:823-826
    [10]
    Sando R, Baumgaertel K, Pieraut S, Torabi-Rander N, Wandless TJ, Mayford M, Maximov A (2013) Inducible control of gene expression with destabilized Cre. Nat Methods 10:1085-1088
    [11]
    Senturk S, Shirole NH, Nowak DG, Corbo V, Pal D, Vaughan A, Tuveson DA, Trotman LC, Kinney JB, Sordella R (2017) Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization. Nat Commun 8:1-10
    [12]
    Xu CL, Qi XL, Du XG, Zou HY, Gao F, Feng T, Lu HX, Li SL, An XM, Zhang LJ et al (2017) piggyBac mediates efficient in vivo CRISPR library screening for tumorigenesis in mice. Proc Natl Acad Sci USA 114:722-727
    [13]
    Zetsche B, Volz SE, Zhang F (2015) A split-Cas9 architecture for inducible genome editing and transcription modulation. Nat Biotechnol 33:139-142
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