Polycomb chromobox Cbx2 enhances antiviral innate immunity by promoting Jmjd3-mediated demethylation of H3K27 at the <em>Ifnb</em> promoter

Donghao Sun; Xuetao Cao; Chunmei Wang

doi:10.1007/s13238-018-0581-0

Volume 10 Issue 4

Apr. 2019

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Article Navigation > Protein&Cell > 2019 > 10(4): 285-294

Donghao Sun, Xuetao Cao, Chunmei Wang. Polycomb chromobox Cbx2 enhances antiviral innate immunity by promoting Jmjd3-mediated demethylation of H3K27 at the Ifnb promoter[J]. Protein&Cell, 2019, 10(4): 285-294. doi: 10.1007/s13238-018-0581-0

Citation:

Donghao Sun, Xuetao Cao, Chunmei Wang. Polycomb chromobox Cbx2 enhances antiviral innate immunity by promoting Jmjd3-mediated demethylation of H3K27 at the Ifnb promoter[J]. Protein&Cell, 2019, 10(4): 285-294. doi: 10.1007/s13238-018-0581-0

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Polycomb chromobox Cbx2 enhances antiviral innate immunity by promoting Jmjd3-mediated demethylation of H3K27 at the Ifnb promoter

doi: 10.1007/s13238-018-0581-0

Department of Immunology and Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China

Funds:

the National 135 Major Project of China (2017ZX10102032-002)

and CAMS Innovation Fund for Medical Science (2016-I2M-1-003).

This work was supported by grants from the National Natural Science Foundation of China (Grant Nos. 31770944 and 81788101)

Received Date: 2018-06-26

Abstract

Abstract

Polycomb chromobox (CBX) proteins regulate gene transcription by maintaining chromatin states, which guide a variety of biological processes. Now, epigenetic regulation of innate immune response is an emerging field. However, the role of CBX proteins in innate immunity remains unclear. We confirmed that the expression of CBX family proteins, especially Cbx2, was decreased in macrophages upon viral infection, and then we investigated the role of Cbx2 in the antiviral immune response. Silencing or knockdown of Cbx2 in macrophages inhibited virus-induced production of IFN-β. Furthermore, heterozygous Cbx2 knockout were susceptible to VSV challenge. Mechanistically, Cbx2 binds to and recruits Jmjd3 to the Ifnb promoter, leading to demethylation of H3K27me3 and increased transcription of IFN-β. Together, our study reveals a nontraditional function of a Cbx protein and adds new insight into the epigenetic regulation of antiviral innate immunity.
- Cbx2,
- Jmjd3,
- interferon beta,
- innate immunity

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References(30)

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