Volume 11 Issue 8
Aug.  2020
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Qingjun Liu, Zhongjie Sun, Ligong Chen. Memory T cells: strategies for optimizing tumor immunotherapy[J]. Protein&Cell, 2020, 11(8): 549-564. doi: 10.1007/s13238-020-00707-9
Citation: Qingjun Liu, Zhongjie Sun, Ligong Chen. Memory T cells: strategies for optimizing tumor immunotherapy[J]. Protein&Cell, 2020, 11(8): 549-564. doi: 10.1007/s13238-020-00707-9

Memory T cells: strategies for optimizing tumor immunotherapy

doi: 10.1007/s13238-020-00707-9
Funds:

This work was supported by Nation Science and Technology Major Projects for Major New Drugs Innovation and Development (2018ZX09711003-004-002 to L.C.) and by Newish Technology (Beijing) Co.

  • Received Date: 2019-12-31
  • Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells. Furthermore, the Tcm/Teff ratio has been reported to be a predictive biomarker of immune responses against some tumors. Thus, a system-level understanding of the mechanisms underlying the differentiation of effector and memory T cells is of increasing importance for developing immunological strategies against various tumors. This review focuses on recent advances in efficacy against tumors, the origin, formation mechanisms of memory T cells, and the role of the gut microbiota in memory T cell formation. Furthermore, we summarize strategies to generate memory T cells in (ex) vivo that, might be applicable in clinical practice.
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