Volume 11 Issue 5
May  2020
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Article Contents
Nan Wang, Wenyuan Chen, Ling Zhu, Dongjie Zhu, Rui Feng, Jialing Wang, Bin Zhu, Xinzheng Zhang, Xiaoqing Chen, Xianjie Liu, Runbin Yan, Dongyao Ni, Grace Guoying Zhou, Hongrong Liu, Zihe Rao, Xiangxi Wang. Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation[J]. Protein&Cell, 2020, 11(5): 366-373. doi: 10.1007/s13238-020-00711-z
Citation: Nan Wang, Wenyuan Chen, Ling Zhu, Dongjie Zhu, Rui Feng, Jialing Wang, Bin Zhu, Xinzheng Zhang, Xiaoqing Chen, Xianjie Liu, Runbin Yan, Dongyao Ni, Grace Guoying Zhou, Hongrong Liu, Zihe Rao, Xiangxi Wang. Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation[J]. Protein&Cell, 2020, 11(5): 366-373. doi: 10.1007/s13238-020-00711-z

Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation

doi: 10.1007/s13238-020-00711-z
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We thank Xiaojun Huang, Boling Zhu, Tongxin Niu and Deyin Fan for cryo-EM technical supports. The cryo-EM data sets were collected at Center for Biological imaging (CBI), Institute of Biophysics. Work was supported by the Key Programs of the Chinese Academy (KJZD-SW-L05), the Strategic Priority Research Program (XDB29010000), National Key Research and Development Program (2018YFA0900801 and 2017YFC0840300), National Natural Science Foundation of China (31800145 and 81520108019) and National Science Foundation of Hunan Province, China (2019JJ10002). Ling Zhu was sponsored by the Youth Innovation Promotion Association at the Chinese Academy of Science. Xiangxi Wang was supported by Ten Thousand Talent Program and the NSFS Innovative Research Group (No. 81921005).

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  • [1]
    Aksyuk AA, Newcomb WW, Cheng N, Winkler DC, Fontana J, Heymann JB, Steven AC (2015) Subassemblies and asymmetry in assembly of herpes simplex virus procapsid. mBio 6:e01525-15
    [2]
    Chayavichitsilp P, Buckwalter JV, Krakowski AC, Friedlander SF (2009) Herpes simplex. Pediatr Rev 30:119-129; quiz 130
    [3]
    Chen W, Xiao H, Wang X, Song S, Han Z, Li X, Yang F, Wang L, Song J, Liu H et al (2020) Structural changes of a bacteriophage upon DNA packaging and maturation. Protein Cell. https://doi.org/10.1007/s13238-020-00715-9
    [4]
    Gong D, Dai X, Jih J, Liu YT, Bi GQ, Sun R, Zhou ZH (2019) DNA-packing portal and capsid-associated tegument complexes in the tumor herpesvirus KSHV. Cell 178:1329-1343.e12
    [5]
    Lee CS, Guo P (1995) Sequential interactions of structural proteins in phage phi 29 procapsid assembly. J Virol 69:5024-5032
    [6]
    Liu YT, Jih J, Dai X, Bi GQ, Zhou ZH (2019) Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome. Nature 570:257-261
    [7]
    Lokareddy RK, Sankhala RS, Roy A, Afonine PV, Motwani T, Teschke CM, Parent KN, Cingolani G (2017) Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation. Nat Commun 8:14310
    [8]
    McElwee M, Vijayakrishnan S, Rixon F, Bhella D (2018) Structure of the herpes simplex virus portal-vertex. PLoS Biol 16:e2006191
    [9]
    Newcomb WW, Homa FL, Brown JC (2005) Involvement of the portal at an early step in herpes simplex virus capsid assembly. J Virol 79:10540-10546
    [10]
    Schmid MF, Hecksel CW, Rochat RH, Bhella D, Chiu W, Rixon FJ (2012) A tail-like assembly at the portal vertex in intact herpes simplex type-1 virions. PLoS Pathog 8:e1002961
    [11]
    Wang JL, Yuan S, Zhu DJ, Tang H, Wang N, Chen WY, Gao Q, Li YH, Wang JZ, Liu HR et al (2018) Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component. Nat Commun 9:3668
    [12]
    Yang Y, Yang P, Wang N, Zhu L, Zeng Y, Rao Z, Wang X (2020) Architecture of the herpesvirus genome-packaging complex and implications for DNA translocation. Protein Cell. https://doi.org/10.1007/s13238-020-00710-0
    [13]
    Yu X, Jih J, Jiang J, Zhou ZH (2017) Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150. Science. https://doi.org/10.1126/science.aam6892
    [14]
    Yuan S, Wang J, Zhu D, Wang N, Gao Q, Chen W, Tang H, Wang J, Zhang X, Liu H et al (2018) Cryo-EM structure of a herpesvirus capsid at 3.1 A. Science. https://doi.org/10.1126/science.aao7283
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