Volume 12 Issue 7
Jul.  2021
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Linsen Li, Mindan Tong, Yuhui Fu, Fang Chen, Shen Zhang, Hanmo Chen, Xi Ma, Defa Li, Xiaoxia Liu, Qing Zhong. Lipids and membrane-associated proteins in autophagy[J]. Protein&Cell, 2021, 12(7): 520-544. doi: 10.1007/s13238-020-00793-9
Citation: Linsen Li, Mindan Tong, Yuhui Fu, Fang Chen, Shen Zhang, Hanmo Chen, Xi Ma, Defa Li, Xiaoxia Liu, Qing Zhong. Lipids and membrane-associated proteins in autophagy[J]. Protein&Cell, 2021, 12(7): 520-544. doi: 10.1007/s13238-020-00793-9

Lipids and membrane-associated proteins in autophagy

doi: 10.1007/s13238-020-00793-9

The work was supported by grants from NSFC (91754205, 91957204, 31771523, 31870830 and 31801170), MOST (2019YFA0508602), Shanghai Municipal Science and Technology Project (20JC1411100), Program of Shanghai Academic/Technology Research Leader (19XD1402200) and innovative research team of high-level local universities in Shanghai.

  • Received Date: 2020-07-02
  • Rev Recd Date: 2020-08-07
  • Publish Date: 2021-07-08
  • Autophagy is essential for the maintenance of cellular homeostasis and its dysfunction has been linked to various diseases. Autophagy is a membrane driven process and tightly regulated by membrane-associated proteins. Here, we summarized membrane lipid composition, and membrane-associated proteins relevant to autophagy from a spatiotemporal perspective. In particular, we focused on three important membrane remodeling processes in autophagy, lipid transfer for phagophore elongation, membrane scission for phagophore closure, and autophagosome-lysosome membrane fusion. We discussed the significance of the discoveries in this field and possible avenues to follow for future studies. Finally, we summarized the membrane-associated biochemical techniques and assays used to study membrane properties, with a discussion of their applications in autophagy.
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