Volume 12 Issue 9
Sep.  2021
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Shiyu Xia, Zhenhang Chen, Chen Shen, Tian-Min Fu. Higher-order assemblies in immune signaling:supramolecular complexes and phase separation[J]. Protein&Cell, 2021, 12(9): 680-694. doi: 10.1007/s13238-021-00839-6
Citation: Shiyu Xia, Zhenhang Chen, Chen Shen, Tian-Min Fu. Higher-order assemblies in immune signaling:supramolecular complexes and phase separation[J]. Protein&Cell, 2021, 12(9): 680-694. doi: 10.1007/s13238-021-00839-6

Higher-order assemblies in immune signaling:supramolecular complexes and phase separation

doi: 10.1007/s13238-021-00839-6

T.M.F. is supported by the Ohio State University Startup fund and C. S. is supported by a Cancer Research Institute Irvington Postdoctoral Fellowship. We apologize for incomplete citations due to space limitations.

  • Received Date: 2020-12-03
  • Accepted Date: 2021-03-01
  • Signaling pathways in innate and adaptive immunity play vital roles in pathogen recognition and the functions of immune cells. Higher-order assemblies have recently emerged as a central principle that governs immune signaling and, by extension, cellular communication in general. There are mainly two types of higherorder assemblies:1) ordered, solid-like large supramolecular complexes formed by stable and rigid protein-protein interactions, and 2) liquid-like phaseseparated condensates formed by weaker and more dynamic intermolecular interactions. This review covers key examples of both types of higher-order assemblies in major immune pathways. By placing emphasis on the molecular structures of the examples provided, we discuss how their structural organization enables elegant mechanisms of signaling regulation.
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