Volume 12 Issue 11
Nov.  2021
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Guang Lei, Chao Mao, Yuelong Yan, Li Zhuang, Boyi Gan. Ferroptosis, radiotherapy, and combination therapeutic strategies[J]. Protein&Cell, 2021, 12(11): 836-857. doi: 10.1007/s13238-021-00841-y
Citation: Guang Lei, Chao Mao, Yuelong Yan, Li Zhuang, Boyi Gan. Ferroptosis, radiotherapy, and combination therapeutic strategies[J]. Protein&Cell, 2021, 12(11): 836-857. doi: 10.1007/s13238-021-00841-y

Ferroptosis, radiotherapy, and combination therapeutic strategies

doi: 10.1007/s13238-021-00841-y
Funds:

B.G. is supported by Radiation Oncology Strategic Initiatives (ROSI) from The University of Texas MD Anderson Cancer Center.

  • Received Date: 2021-02-18
  • Rev Recd Date: 2021-03-29
  • Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression, and to mediate the synergy between radiotherapy and immunotherapy. In this review, we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and ferroptosis, discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy, and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy. This review will provide important frameworks for future investigations of ferroptosis in cancer therapy.
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