Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques

doi: 10.1093/procel/pwac020

• Dali Tong¹ , 
• Mei Zhang^1,2 , 
• Yunru Yang^1,2 , 
• Han Xia^3,4 , 
• Haiyang Tong⁵ , 
• Huajun Zhang⁴ , 
• Weihong Zeng² , 
• Muziying Liu⁶ , 
• Yan Wu⁴ , 
• Huan Ma² , 
• Xue Hu³ , 
• Weiyong Liu¹ , 
• Yuan Cai¹ , 
• Yanfeng Yao⁴ , 
• Yichuan Yao^1,2 , 
• Kunpeng Liu³ , 
• Shifang Shan⁷ , 
• Yajuan Li⁸ , 
• Ge Gao⁴ , 
• Weiwei Guo³ , 
• Yun Peng⁴ , 
• Shaohong Chen³ , 
• Juhong Rao³ , 
• Jiaxuan Zhao³ , 
• Juan Min⁴ , 
• Qingjun Zhu⁵ , 
• Yanmin Zheng⁵ , 
• Lianxin Liu¹ , 
• Chao Shan³ , 
• Kai Zhong⁵ , 
• Zilong Qiu^{7 ,  ,}  , 
• Tengchuan Jin^{1,2 ,  ,}  , 
• Sandra Chiu^{1,2 ,  ,}  , 
• Zhiming Yuan^{4 ,  ,}  , 
• Tian Xue^{1,2,7,9 ,  ,} 

• 1 First Affiliated Hospital of USTC, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China;

• 2 Hefei National Research Center for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, CAS Key Laboratory of Brain Function and Disease, CAS Key Laboratory of Innate Immunity and Chronic Disease, Biomedical Sciences and Health Laboratory of Anhui Province, University of Science and Technology of China, Hefei 230026, China;

• 3 State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China;

• 4 Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China;

• 5 Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China;

• 6 Anhui Institute of Pediatric Research, Anhui Provincial Children's Hospital, Hefei 230051, China;

• 7 Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China;

• 8 Department of Clinical Laboratory, First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China;

• 9 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China