Protein&Cell

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CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

Puping Liang, Yanwen Xu, Xiya Zhang, Chenhui Ding, Rui Huang, Zhen Zhang, Jie Lv, Xiaowei Xie, Yuxi Chen, Yujing Li, Ying Sun, Yaofu Bai, Zhou Songyang, Wenbin Ma, Canquan Zhou, Junjiu Huang

2015, 6(5): 363-372. doi: 10.1007/s13238-015-0153-5

[Abstract](423) [PDF 1222KB](227041)

Correction of β-thalassemia mutant by base editor in human embryos

Puping Liang, Chenhui Ding, Hongwei Sun, Xiaowei Xie, Yanwen Xu, Xiya Zhang, Ying Sun, Yuanyan Xiong, Wenbin Ma, Yongxiang Liu, Yali Wang, Jianpei Fang, Dan Liu, Zhou Songyang, Canquan Zhou, Junjiu Huang

2017, 8(11): 811-822. doi: 10.1007/s13238-017-0475-6

[Abstract](354) [PDF 1967KB](49014)

Questions about NgAgo

Shawn Burgess, Linzhao Cheng, Feng Gu, Junjiu Huang, Zhiwei Huang, Shuo Lin, Jinsong Li, Wei Li, Wei Qin, Yujie Sun, Zhou Songyang, Wensheng Wei, Qiang Wu, Haoyi Wang, Xiaoqun Wang, Jing-Wei Xiong, Jianzhong Xi, Hui Yang, Bin Zhou, Bo Zhang

2016, 7(12): 913-915. doi: 10.1007/s13238-016-0343-9

[Abstract](241) [PDF 857KB](18005)

Current progress in innovative engineered antibodies

R. Strohl William

2018, 9(1): 86-120. doi: 10.1007/s13238-017-0457-8

[Abstract](260) [FullText HTML](34) [PDF 1247KB](17006)

The regulation of TGF-β/SMAD signaling by protein deubiquitination

Juan Zhang, Xiaofei Zhang, Feng Xie, Zhengkui Zhang, Hans van Dam, Long Zhang, Fangfang Zhou

2014, 5(7): 503-517. doi: 10.1007/s13238-014-0058-8

[Abstract](202) [PDF 510KB](16010)

T-cell receptor-engineered T cells for cancer treatment: current status and future directions

Yu Ping, Chaojun Liu, Yi Zhang

2018, 9(3): 254-266. doi: 10.1007/s13238-016-0367-1

[Abstract](197) [PDF 1034KB](14010)

Antibody-drug conjugates: recent advances in conjugation and linker chemistries

Kyoji Tsuchikama, Zhiqiang An

2018, 9(1): 33-46. doi: 10.1007/s13238-016-0323-0

[Abstract](106) [PDF 949KB](12023)

Hemagglutinin-esterase-fusion (HEF) protein of influenza C virus

Mingyang Wang, Michael Veit

2016, 7(1): 28-45. doi: 10.1007/s13238-015-0193-x

[Abstract](144) [PDF 2589KB](12006)

Regeneration of functional alveoli by adult human SOX9⁺ airway basal cell transplantation

Qiwang Ma, Yu Ma, Xiaotian Dai, Tao Ren, Yingjie Fu, Wenbin Liu, Yufei Han, Yingchuan Wu, Yu Cheng, Ting Zhang, Wei Zuo

2018, 9(3): 267-282. doi: 10.1007/s13238-018-0506-y

[Abstract](377) [PDF 3771KB](10041)

The moral imperative to continue gene editing research on human embryos

Julian Savulescu, Jonathan Pugh, Thomas Douglas, Christopher Gyngell

2015, 6(7): 476-479. doi: 10.1007/s13238-015-0184-y

[Abstract](104) [PDF 228KB](9503)

Advancing chimeric antigen receptor T cell therapy with CRISPR/Cas9

Jiangtao Ren, Yangbing Zhao

2017, 8(9): 634-643. doi: 10.1007/s13238-017-0410-x

[Abstract](198) [PDF 488KB](8107)

Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins

Liming Liu

2018, 9(1): 15-32. doi: 10.1007/s13238-017-0408-4

[Abstract](198) [PDF 1150KB](8008)

The crystal structure of Zika virus helicase: basis for antiviral drug design

Hongliang Tian, Xiaoyun Ji, Xiaoyun Yang, Wei Xie, Kailin Yang, Cheng Chen, Chen Wu, Heng Chi, Zhongyu Mu, Zefang Wang, Haitao Yang

2016, 7(6): 450-454. doi: 10.1007/s13238-016-0275-4

[Abstract](141) [PDF 0KB](7601)

Homologous recombination in human embryonic stem cells using CRISPR/Cas9 nickase and a long DNA donor template

Zhili Rong, Shengyun Zhu, Yang Xu, Xuemei Fu

2014, 5(4): 258-260. doi: 10.1007/s13238-014-0032-5

[Abstract](109) [PDF 292KB](7402)

Human gut microbiota: the links with dementia development

Rashad Alkasir, Jing Li, Xudong Li, Miao Jin, Baoli Zhu

2017, 8(2): 90-102. doi: 10.1007/s13238-016-0338-6

[Abstract](173) [PDF 938KB](7108)

The hierarchy quorum sensing network in Pseudomonas aeruginosa

asmine Lee, Lianhui Zhang

2015, 6(1): 26-41. doi: 10.1007/s13238-014-0100-x

[Abstract](139) [PDF 632KB](6505)

Urgency to rein in the gene-editing technology

Xiaoxue Zhang

2015, 6(5): 313-313. doi: 10.1007/s13238-015-0161-5

[Abstract](94) [PDF 190KB](6200)

Driver mutations of cancer epigenomes

David M. Roy, Logan A. Walsh, Timothy A. Chan

2014, 5(4): 265-296. doi: 10.1007/s13238-014-0031-6

[Abstract](166) [PDF 893KB](6106)

Jian-Kang Liu: A pioneer of sex determination studies in vertebrates

Li Zhou, Jian-Fang Gui

2016, 7(1): 1-3. doi: 10.1007/s13238-015-0232-7

[Abstract](123) [PDF 721KB](5500)

In vitro expression and analysis of the 826 human G protein-coupled receptors

Xuechen Lv, Junlin Liu, Qiaoyun Shi, Qiwen Tan, Dong Wu, John J. Skinner, Angela L. Walker, Lixia Zhao, Xiangxiang Gu, Na Chen, Lu Xue, Pei Si, Lu Zhang, Zeshi Wang, Vsevolod Katritch, Zhi-jie Liu, Raymond C. Stevens

2016, 7(5): 325-337. doi: 10.1007/s13238-016-0263-8

[Abstract](195) [PDF 784KB](5409)

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Current Issue

March, 2021

Volume 12, Issue 3

Pages 159-235

About the cover

Paving the way towards cancer: 11q13 amplicon fuels cancer cells with SHANK2 to dislodge HIPPO. Certain oncogenes are amplified in cancer cells to promote tumorigenesis. Xu et al. demonstrated that amongst genes on the 11q13 tumor amplicon, SHANK2 is the most frequently amplified gene in human cancers and acts as an oncogene. SHANK2 is a novel and evlutionarily conserved regulator of HIPPO pathway. Through competitive binding, overexpressed SHANK2 displaces LATS kinase from its activator, thereby librating YAP to promote tumor formation.

Page 159

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