2019 Vol. 10, No. 2

It is well accepted that Quorum Sensing (QS) is a vital processin bacteria. Remarkably, a recent report described the use ofa QS system for regulation of entry into lytic or lysogenic cycleby the Bacillus-infecting temperate phages phi3T and SPbeta.AimR, encoding the intracellular receptor of AimP, is predictedto be structurally similar to RRNPP regulators. In this issue,Zhen et al. solved the crystal structure of apo AimR as well asAimR-AimP complex, which provide insights into the molecularmechanism underlying the switch between lytic and lysogeniccycles mediated by this arbitrium system.
Down-regulation of the let-7i facilitates gastric cancer invasion and metastasis by targeting COL1A1
2019, 10(2): 143-148.
doi: 10.1007/s13238-018-0550-7
Abstract: