2023, Volume 14, Issue 1
A recurrent outbreak of viral infections in recent years is an important public health problem, e.g., SARS and COVID-19. However, current therapy strategy is limited to a minority of patients and associated with side effects and toxicities. Prof. Xu and her co-authors found that PAC5, derived from medical plant and as a first-in-class drug, can turns on the innate immune to eliminate the virus by binding to and activating hnRNPA2B1. The cover is in the form of a comic to describe a story of Shennong Fighting Demons used as a metaphor for the study. Legend has it that Shennong is the founder of Chinese medicine. Defeated Monsters represent viruses. Four half-eighttrigrams graphs represent inactivated hnRNPA2B1, and two complete eighttrigrams graphs represent hnRNPA2B1 activated by PAC5. The circle around Shennong metaphorically shows the binding of PAC5 to hnRNPA2B1 for antiviral immunotherapy. The cover highlights traditional Chinese medicine not only being a source of innovative drug discovery, but also being used as probes to find the new drug target.