2022 Vol. 13, No. 11
Hematopoietic stem cell transplantation has been successfully employed in treating hematological diseases. However, approximately 5%–46% of donors fail to mobilize their HSPCs. Xu et al. developed a polypeptide-forming three-dimension culture system (3DCS) to efficiently expand rare HSPCs circulating in steady peripheral blood (cHSPCs). The 3DCS fabricated an immunomodulatory niche (the soil), secreting cytokines as TNF-α to support the survival and multi-lineage differentiation (apples on the tree) of cHSPCs (the seed) in patients/donors who have failed in HSPC mobilization.