Volume 7 Issue 9
Sep.  2016
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Jing-Peng Fu, Wei-Chuan Mo, Ying Liu, Perry F. Bartlett, Rong-Qiao He. Elimination of the geomagnetic field stimulates the proliferation of mouse neural progenitor and stem cells[J]. Protein&Cell, 2016, 7(9): 624-637. doi: 10.1007/s13238-016-0300-7
Citation: Jing-Peng Fu, Wei-Chuan Mo, Ying Liu, Perry F. Bartlett, Rong-Qiao He. Elimination of the geomagnetic field stimulates the proliferation of mouse neural progenitor and stem cells[J]. Protein&Cell, 2016, 7(9): 624-637. doi: 10.1007/s13238-016-0300-7

Elimination of the geomagnetic field stimulates the proliferation of mouse neural progenitor and stem cells

doi: 10.1007/s13238-016-0300-7
Funds:

This work is funded by:The External Cooperation Program of BIC, Chinese Academy of Sciences (Grant No. GJHZ201302), the project of Chinese Academy of Sciences for the development of major scientific research equipment (Grant No. YZ201148), the National Natural Science Foundation of China (Grant Nos. 31200628 and 31271387), and the Queensland-Chinese Academy of Sciences Biotechnology Fund (Grant No. GJHZ1131).

  • Received Date: 2016-06-04
  • Rev Recd Date: 2016-07-07
  • Living organisms are exposed to the geomagnetic field (GMF) throughout their lifespan. Elimination of the GMF, resulting in a hypogeomagnetic field (HMF), leads to central nervous system dysfunction and abnormal development in animals. However, the cellular mechanisms underlying these effects have not been identified so far. Here, we show that exposure to an HMF (<200 nT), produced by a magnetic field shielding chamber, promotes the proliferation of neural progenitor/stem cells (NPCs/NSCs) from C57BL/6 mice. Following seven-day HMF-exposure, the primary neurospheres (NSs) were significantly larger in size, and twice more NPCs/NSCs were harvested from neonatal NSs, when compared to the GMF controls. The self-renewal capacity and multipotency of the NSs were maintained, as HMF-exposed NSs were positive for NSC markers (Nestin and Sox2), and could differentiate into neurons and astrocyte/glial cells and be passaged continuously. In addition, adult mice exposed to the HMF for one month were observed to have a greater number of proliferative cells in the subventricular zone. These findings indicate that continuous HMF-exposure increases the proliferation of NPCs/NSCs, in vitro and in vivo. HMF-disturbed NPCs/NSCs production probably affects brain development and function, which provides a novel clue for elucidating the cellular mechanisms of the bio-HMF response.
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