Volume 12 Issue 3
Mar.  2021
Turn off MathJax
Article Contents
Jane Y. Wu. Tongue as a first-line immune organ?[J]. Protein&Cell, 2021, 12(3): 162-164. doi: 10.1007/s13238-020-00802-x
Citation: Jane Y. Wu. Tongue as a first-line immune organ?[J]. Protein&Cell, 2021, 12(3): 162-164. doi: 10.1007/s13238-020-00802-x

Tongue as a first-line immune organ?

doi: 10.1007/s13238-020-00802-x
Funds:

The author apologizes to researchers whose studies could not be directly cited because of the space limit. The author is grateful to Dr. Aaron Ciechanover, Dr. Lily Jan, Dr. Eric Nestler, Dr. Arnold Strauss and Dr. Michael Young for critical reading and helpful comments and to NIH (R01NS107396

R56AG063934).

R56AG061327

  • Received Date: 2020-10-27
  • Publish Date: 2021-03-12
  • loading
  • [1]
    Camandola S, Mattson MP (2017) Toll-like receptor 4 mediates fat, sugar, and umami taste preference and food intake and body weight regulation. Obesity 25(7):1237-1245
    [2]
    Cao X (2020) COVID-19:immunopathology and its implications for therapy. Nat Rev Immunol. https://doi.org/10.1038/s41577-020-0308-3
    [3]
    Carey RM, Lee RJ (2019) Taste receptors in upper airway innate immunity. Nutrients 11(9):2017
    [4]
    Cuburu N, Kweon MN, Song JH, Hervouet C, Luci C, Sun JB, Hofman P, Holmgren J, Anjuère F, Czerkinsky C (2007) Sublingual immunization induces broad-based systemic and mucosal immune responses in mice. Vaccine 25(51):8598-8610
    [5]
    Czerkinsky C, Cuburu N, Kweon MN, Anjuere F, Holmgren J (2011) Sublingual vaccination. Hum Vaccin 7(1):110-114
    [6]
    Freund JR, Mansfield CJ, Doghramji LJ, Adappa ND, Palmer JN, Kennedy DW, Reed DR, Jiang P, Lee RJ (2018) Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling. J Biol Chem 293(25):9824-9840
    [7]
    Gondak RO, Alves DB, Silva LF, Mauad T, Vargas PA (2012) Depletion of Langerhans cells in the tongue from patients with advanced-stage acquired immune deficiency syndrome:relation to opportunistic infections. Histopathology 60(3):497-503
    [8]
    Grassin-Delyle S, Salvator H, Mantov N, Abrial C, Brollo M, Faisy C, Naline E, Couderc LJ, Devillier P (2019) Bitter taste receptors (TAS2Rs) in human lung macrophages:receptor expression and inhibitory effects of TAS2R agonists. Front Physiol 10:1267
    [9]
    Iemoli E, Borgonovo L, Fusi A, Magni C, Ricci ED, Rizzardini G, Piconi S (2016) Sublingual allergen immunotherapy in HIVpositive patients. Allergy 71(3):412-415
    [10]
    Jones AT, Shen X, Walter KL, LaBranche CC, Wyatt LS, Tomaras GD, Montefiori DC, Moss B, Barouch DH, Clements JD et al (2019) HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge. Nat Commun 10(1):798
    [11]
    Malki A, Fiedler J, Fricke K, Ballweg I, Pfaffl MW, Krautwurst D (2015) Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes. J Leukoc Biol 97:533-545
    [12]
    McCluskie MJ, Brazolot Millan CL, Gramzinski RA, Robinson HL, Santoro JC, Fuller JT, Widera G, Haynes JR, Purcell RH, Davis HL (1999) Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates. Mol Med 5(5):287-300
    [13]
    Orsmark-Pietras C, James A, Konradsen JR, Nordlund B, Soderhall C, Pulkkinen V, Daham K, Kupczyk M, Dahlén B, Kere J (2013) Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics. Eur Respir J 42:65-78
    [14]
    Park A, Iwasaki A (2020) Type I and Type III interferons-induction, signaling, evasion, and application to combat COVID-19. Cell Host Microbe 27(6):870-878
    [15]
    Roper SD, Chaudhari N (2017) Taste buds:cells, signals and synapses. Nat Rev Neurosci 18(8):485-497
    [16]
    Scheiblhofer S, Thalhamer J, Weiss R (2018) DNA and mRNA vaccination against allergies. Pediatr Allergy Immunol 29(7):679-688
    [17]
    Shaikh N, Rivera J, Hewlett BR, Stead RH, Zhu FG, Marshall JS (1997) Mast cell Fc epsilonRI expression in the rat intestinal mucosa and tongue is enhanced during Nippostrongylus brasiliensis infection and can be up-regulated by in vivo administration of IgE. J Immunol 158(8):3805-3812
    [18]
    Thirion-Delalande C, Gervais F, Fisch C, Cuiné J, Baron-Bodo V, Moingeon P, Mascarell L (2017) Comparative analysis of the oral mucosae from rodents and non-rodents:application to the nonclinical evaluation of sublingual immunotherapy products. PLoS ONE 12(9):e0183398
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)

    Article Metrics

    Article views (104) PDF downloads(16) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return